Analytical Data
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Gene name
KCNN4
- Application
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Alternative Names
IKCa1 (IK1) (KCa3.1) (KCa4) (Putative Gardos channel) (IK1) (IKCA1) (KCA4) (SK4) (SK4) (SKCa 4) (SKCa4)
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Species
Human
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Source
E. coli
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O15554
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Expression Region
1-427aa
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Molecular Weight
53.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
KCNN4, also known as the intermediate-conductance calcium-activated potassium channel, plays a significant role in various physiological and pathological processes. It is primarily expressed in tissues such as the brain, heart, and immune cells, where it contributes to the regulation of membrane potential and cellular excitability. Research has shown that KCNN4 is involved in critical functions including cellular proliferation, migration, and apoptosis, making it a target of interest in cancer biology and cardiovascular research. Its dysregulation has been implicated in numerous conditions, including hypertension, heart failure, and certain malignancies. Moreover, KCNN4 interacts with various signaling pathways, impacting immune responses and neuronal functions. This has spurred interest in developing KCNN4-targeting biomolecules to explore potential therapeutic applications. The recombinant protein of KCNN4 serves as a valuable tool for studying its functional properties, structure, and interactions with pharmacological agents. By elucidating the mechanisms underlying KCNN4's activity, researchers aim to uncover novel approaches for modulating its function in disease contexts, paving the way for innovative treatment strategies.
