Analytical Data
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基因名
KCNK3
- Application
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别名
Acid-sensitive potassium channel protein TASK-1 (TWIK-related acid-sensitive K(+) channel 1) (Two pore potassium channel KT3.1) (Two pore K(+) channel KT3.1) (TASK) (TASK1)
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种属
Human
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表达系统
E. coli
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标签
N- His & C- Myc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O14649
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表达区间
1-394aa
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分子量
50.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KCNK3, also known as K+ channel, subfamily K, member 3, is a member of the two-pore domain potassium (K2P) channel family that plays a critical role in regulating cellular excitability and maintaining resting membrane potential. It is primarily expressed in the brain and lungs, where it contributes to the modulation of neuronal activity and pulmonary function, respectively. Alterations in KCNK3 expression or function have been associated with various pathophysiological conditions, including pulmonary arterial hypertension (PAH) and neurological disorders. The study of KCNK3 recombinant proteins has garnered attention as a means to elucidate its structural and functional properties, potentially leading to novel therapeutic targets. By producing and characterizing KCNK3 recombinant proteins, researchers aim to explore its ion conducting mechanisms, pharmacological properties, and the impact of specific mutations. This research not only enhances our understanding of KCNK3's role in health and disease but also paves the way for the development of targeted therapies for conditions associated with its dysregulation. Thus, KCNK3 has emerged as a significant focus in the field of biomedical research, with ongoing studies aimed at leveraging its potential for therapeutic intervention.
