Analytical Data
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Gene name
MAPK8
- Application
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Alternative Names
JNK-46 Stress-activated protein kinase 1c Short name: SAPK1c Stress-activated protein kinase JNK1 c-Jun N-terminal kinase 1
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Species
Human
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Source
Baculovirus
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P45983
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Expression Region
4-422aa
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Molecular Weight
49.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
MAPK8, also known as Jun N-terminal kinase 1 (JNK1), is a member of the mitogen-activated protein kinase (MAPK) family that plays a crucial role in various cellular processes such as inflammation, apoptosis, and stress responses. Research into MAPK8's functionality has gained momentum due to its implication in numerous diseases, including cancer, neurodegenerative disorders, and metabolic syndromes. The ability of MAPK8 to mediate signal transduction in response to environmental stresses makes it a vital target for therapeutic interventions. In recent years, the recombinant expression and purification of MAPK8 have become essential for understanding its mechanism of action, interactions with downstream substrates, and regulatory pathways. The development of recombinant MAPK8 proteins allows researchers to study its activity in controlled environments, facilitating the exploration of its structure-function relationship and potential inhibitory compounds. Advances in biotechnological tools have enhanced the efficiency of producing functional MAPK8, providing insights into its role in cellular signaling networks and offering a basis for developing novel therapeutic strategies aimed at modulating MAPK8 activity in diseases where its dysregulation is evident. Overall, the study of MAPK8 recombinant proteins is pivotal in elucidating the complexities of MAPK signaling and holds promise for the advancement of targeted treatments in various pathological conditions.
