Analytical Data
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Gene name
HIST1H2AH
- Application
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Alternative Names
H2AFALii; H2A/S
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Species
Human
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Source
E. coli
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Tag
N- His & GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96KK5
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Expression Region
Met1~Lys128
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Molecular Weight
44kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HIST1H2AH is a member of the histone H2A family and plays a critical role in the formation of chromatin, which is essential for the regulation of gene expression, DNA replication, and repair processes. As a core component of the nucleosome, HIST1H2AH contributes to the packaging of DNA into a compact structure, allowing the cell to efficiently manage its genetic material. Research into HIST1H2AH has gained traction as its dysregulation has been implicated in various diseases, including cancer. The study of HIST1H2AH recombinant protein offers valuable insights into its structure-function relationships, post-translational modifications, and interactions with other chromatin-associated proteins. Scientists have also pursued the development of recombinant HIST1H2AH to explore its potential as a therapeutic target or biomarker, given its involvement in epigenetic regulation. Understanding the biology of HIST1H2AH could lead to novel strategies for manipulating gene expression and treating diseases associated with chromatin malfunctions.
