Analytical Data
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Gene name
TIM-4
- Application
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Alternative Names
TIMD-4; TIMD4; TIM-4;
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Species
Cynomolgus
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Source
HEK293
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Tag
C-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
XP_005558436.2
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Expression Region
E25-Q305
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Protein Length
Partial
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Molecular Weight
70-80 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TIM-4, or T cell immunoglobulin and mucin domain-containing protein 4, is a novel receptor primarily expressed on antigen-presenting cells, particularly dendritic cells and macrophages. Its primary function involves binding to phosphatidylserine, a phospholipid that appears on the surface of apoptotic cells, facilitating the clearance of dead or dying cells through a process known as efferocytosis. This interaction is crucial for maintaining immune homeostasis and preventing autoimmune responses. The study of TIM-4 as a recombinant protein has garnered significant interest in recent years due to its potential role in modulating immune responses. Researchers have been investigating TIM-4's ability to influence T cell activation and polarization, with implications for therapeutic strategies in cancer immunotherapy, autoimmunity, and infectious diseases. By manipulating TIM-4 signaling pathways, scientists aim to enhance the efficacy of vaccines and improve outcomes in immune-related therapies. This growing body of research highlights the importance of TIM-4 in the broader context of immune regulation, offering insights into its potential as a biomarker for disease progression and a target for novel interventions aimed at restoring balanced immune responses.
