Analytical Data
-
Gene name
SFRP2
-
简介
The SFRP2 protein belongs to the secreted Frizzled-related protein (sFRP) family and regulates the Wnt signaling pathway and cellular processes. Notably, SFRP2 lacks conserved residues that are critical for feature annotation propagation, suggesting that the sFRP family has unique structural or functional properties. SFRP2 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived SFRP2 protein, expressed by HEK293 , with C-His labeled tag.
- Application
-
Alternative Names
sFRP-2; SARP-1; Sarp1; Sdf5; Sfrp2
-
Species
Cynomolgus
-
Source
HEK293
-
Tag
C-8*His
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
G8F2Z7
-
Expression Region
L25-C295
-
Protein Length
Full Length of Mature Protein
-
Molecular Weight
33-38 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SFRP2 (Secreted Frizzled-Related Protein 2) is a member of the SFRP family, which plays a significant role in the Wnt signaling pathway, a critical regulator of various biological processes, including cell proliferation, differentiation, and apoptosis. Alterations in Wnt signaling are implicated in a range of pathological conditions, such as cancer, where SFRP2 acts as an antagonist of Wnt ligands, potentially influencing tumor progression and metastasis. Research on SFRP2 has gained momentum due to its dual role as both a tumor suppressor and, paradoxically, a contributor to tumorigenesis in certain contexts. The recombinant expression of SFRP2 protein enables detailed studies of its structural and functional characteristics, facilitating the exploration of its interactions with Wnt proteins and other cellular components. By generating SFRP2 as a recombinant protein, scientists aim to elucidate its specific mechanisms in regulatory pathways, assess its potential as a biomarker for cancer diagnosis or prognosis, and investigate its therapeutic applications in cancer treatment. Understanding the multifaceted roles of SFRP2 is crucial for the development of targeted therapies and enhancing our knowledge of tumor biology.
