Analytical Data
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基因名
S100B
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简介
The S100B protein is a small zinc and calcium binding protein abundant in astrocytes with unique calcium and zinc binding sites of varying affinities. Although it binds weakly to calcium, it binds tightly to zinc, and potassium ions antagonize both. S100B Protein, Canine (HEK293, Fc) is the recombinant canine-derived S100B protein, expressed by HEK293 , with N-hFc labeled tag.
- Application
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别名
Protein S100; S100 calcium-binding; NEF; S100; 100beta; S100-B
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种属
Canine
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表达系统
HEK293
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标签
N-hFc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
E2QTP3
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表达区间
S2-E92
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蛋白长度
Full Length of Mature Protein
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分子量
40-45 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
S100B is a member of the S100 family of calcium-binding proteins, predominantly expressed in glial cells and to a lesser extent in neurons. It plays a crucial role in various cellular processes, including regulation of cell growth, differentiation, and apoptosis. Elevated levels of S100B in the bloodstream and cerebrospinal fluid have been associated with neurological disorders such as traumatic brain injury, Alzheimer’s disease, and stroke, making it a potential biomarker for these conditions. The research surrounding recombinant S100B protein focuses on its role in neuroinflammation and neuroprotection, where it can either promote or inhibit neuronal survival depending on the context. Scientists are particularly interested in its interactions with receptors like RAGE (Receptor for Advanced Glycation End Products) and its influence on downstream signaling pathways. Moreover, recombinant S100B serves as a valuable tool in studying its biochemical properties and therapeutic potential, aiding in the development of interventions for related neurodegenerative diseases. Understanding the dual roles of S100B and its downstream effects provides insights into the complex mechanisms of brain pathology, paving the way for novel strategies in diagnostics and treatment. In recent years, advances in protein expression techniques have facilitated the production of high-purity recombinant S100B, enabling more detailed investigations into its functional dynamics and its potential application in clinical settings. As research progresses, exploring the multifaceted roles of S100B may unveil new therapeutic avenues for managing various neurological conditions.
