Analytical Data
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基因名
HIST1H2AC
- Application
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别名
H2AFL; H2A Histone Family Member L
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种属
Human
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表达系统
E. coli
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标签
N- His & GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q93077
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表达区间
Ser2~Lys130
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分子量
44kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HIST1H2AC is a member of the histone H2A family and plays a critical role in the packaging of DNA into chromatin, which is essential for regulating gene expression, DNA replication, and repair. Recent studies have shown that aberrations in histone modifications, including those involving HIST1H2AC, are implicated in various diseases, particularly cancer. The reorganization of histone proteins can affect the accessibility of DNA to transcription machinery, leading to altered gene expression patterns associated with tumorigenesis. Researchers have been increasingly focused on understanding the molecular mechanisms that govern the post-translational modifications of HIST1H2AC, as these modifications can serve as biomarkers for disease progression and therapeutic response. Furthermore, recombinant HIST1H2AC proteins have been produced for biochemical assays and structural studies, allowing scientists to explore the functional consequences of specific modifications in a controlled environment. This research is pivotal for establishing a comprehensive understanding of chromatin dynamics and its impact on cellular processes. As a result, targeting histone modifications, including those by HIST1H2AC, presents a promising avenue for developing novel therapeutic strategies in cancer and other related disorders. Thus, the exploration of HIST1H2AC in both its structural and functional contexts remains a significant focus within the field of epigenetics and molecular biology.
