Analytical Data
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Gene name
HIST1H2AC
- Application
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Alternative Names
H2AFL; H2A Histone Family Member L
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Species
Human
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Source
E. coli
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Tag
N- His & GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q93077
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Expression Region
Ser2~Lys130
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Molecular Weight
44kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
HIST1H2AC is a member of the histone H2A family and plays a critical role in the packaging of DNA into chromatin, which is essential for regulating gene expression, DNA replication, and repair. Recent studies have shown that aberrations in histone modifications, including those involving HIST1H2AC, are implicated in various diseases, particularly cancer. The reorganization of histone proteins can affect the accessibility of DNA to transcription machinery, leading to altered gene expression patterns associated with tumorigenesis. Researchers have been increasingly focused on understanding the molecular mechanisms that govern the post-translational modifications of HIST1H2AC, as these modifications can serve as biomarkers for disease progression and therapeutic response. Furthermore, recombinant HIST1H2AC proteins have been produced for biochemical assays and structural studies, allowing scientists to explore the functional consequences of specific modifications in a controlled environment. This research is pivotal for establishing a comprehensive understanding of chromatin dynamics and its impact on cellular processes. As a result, targeting histone modifications, including those by HIST1H2AC, presents a promising avenue for developing novel therapeutic strategies in cancer and other related disorders. Thus, the exploration of HIST1H2AC in both its structural and functional contexts remains a significant focus within the field of epigenetics and molecular biology.
