Analytical Data
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基因名
PSMD13
- Application
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别名
p40.5; Rpn9; 26S proteasome non-ATPase regulatory subunit 13; 26S proteasome regulatory subunit RPN9
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UNM6
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表达区间
Met1~Thr378
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分子量
47kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PSMD13, a crucial component of the 26S proteasome, plays a vital role in the ubiquitin-proteasome system, which is responsible for the degradation of misfolded and regulatory proteins in eukaryotic cells. This protein is implicated in several cellular processes, including protein quality control, cell cycle regulation, and modulation of various signaling pathways. Research into PSMD13 has gained momentum due to its association with several diseases, particularly cancer and neurodegenerative disorders. Understanding its structure and function is essential for developing therapeutic strategies aimed at manipulating proteasome activity. Recombinant PSMD13 protein is often produced for biochemical assays and structural studies, allowing researchers to explore its interactions with ubiquitin-conjugating enzymes and other proteasomal subunits. By elucidating the role of PSMD13 in protein degradation, scientists hope to uncover novel insights into the pathogenesis of diseases associated with proteasome dysfunction, potentially leading to the identification of new drug targets and therapeutic interventions.
