Analytical Data
-
Gene name
MAGP-2/MFAP5
-
简介
MAGP-2/MFAP5 protein may affect hematopoiesis and participate in blood cell formation. In the cardiovascular system, it regulates growth factors, maintains the integrity of large blood vessels through cell signaling, and contributes to the structural organization of elastin-associated microfibrils. MAGP-2/MFAP5 Protein, Human (HEK293, hFc)is the recombinant human-derived MAGP-2/MFAP5 protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
-
Alternative Names
Microfibrillar-associated protein 5; MFAP-5; MP25; MAGP-2
-
Species
Human
-
Source
HEK293
-
Tag
C-hFc
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q13361-1
-
Expression Region
I22-L173
-
Protein Length
Full Length of Isoform-1 Mature Protein
-
Molecular Weight
32-38 kDa & 55-65 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
MAGP-2 (Microfibril-Associated Glycoprotein 2) and MFAP5 (Microfibril-Associated Protein 5) are crucial components of the extracellular matrix, particularly in elastic tissues such as the aorta and lung. Research on these proteins has gained traction due to their roles in promoting microfibril assembly and influencing connective tissue integrity, which are vital for maintaining the structural and functional properties of elastic fibers. Disrupted expression or mutations in MAGP-2 and MFAP5 have been linked to various pathologies, including cardiovascular diseases and connective tissue disorders. The study of MAGP-2 and MFAP5 recombinant proteins is essential for elucidating their distinct and overlapping functions within the microfibril network. Moreover, such research provides valuable insights into their potential as biomarkers for disease progression and targets for therapeutic intervention. To further understand their structural and functional roles, scientists are developing recombinant protein models to investigate their interactions with other extracellular matrix components and to explore their regulatory mechanisms. This understanding can pave the way for novel therapeutic strategies aimed at addressing conditions associated with elastic fiber dysfunction. Through these studies, researchers hope to establish a clearer connection between the molecular functions of MAGP-2/MFAP5 and the clinical manifestations of related diseases.
