Analytical Data
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基因名
HIST1H2AA
- Application
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别名
H2AFR; H2A Histone Family Member R
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种属
Human
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表达系统
E. coli
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标签
N- His & GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96QV6
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表达区间
Ser2~Lys131
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分子量
44kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HIST1H2AA is a member of the histone H2A family, which plays a crucial role in the structure and function of chromatin in eukaryotic cells. Histones are essential for DNA packaging, regulating gene expression, and maintaining genome stability. The research on HIST1H2AA, specifically its recombinant protein, has gained traction due to its potential implications in various biological processes and diseases. Aberrant expression of histone variants, including HIST1H2AA, has been linked to cancer progression and other pathologies, highlighting the importance of understanding histone dynamics. Recombinant technology allows for the production and study of HIST1H2AA in controlled environments, facilitating investigations into its structural properties, post-translational modifications, and interactions with other chromatin-associated proteins. Furthermore, studies of this histone variant can provide insights into the mechanisms by which histones influence epigenetic regulation and their role in cellular responses to environmental stimuli. Understanding the functional roles of HIST1H2AA could pave the way for novel therapeutic approaches targeting chromatin-related diseases, making it a significant focus of current research in molecular biology and medicine.
