Analytical Data
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Gene name
HIST1H2AA
- Application
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Alternative Names
H2AFR; H2A Histone Family Member R
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Species
Human
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Source
E. coli
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Tag
N- His & GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96QV6
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Expression Region
Ser2~Lys131
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Molecular Weight
44kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HIST1H2AA is a member of the histone H2A family, which plays a crucial role in the structure and function of chromatin in eukaryotic cells. Histones are essential for DNA packaging, regulating gene expression, and maintaining genome stability. The research on HIST1H2AA, specifically its recombinant protein, has gained traction due to its potential implications in various biological processes and diseases. Aberrant expression of histone variants, including HIST1H2AA, has been linked to cancer progression and other pathologies, highlighting the importance of understanding histone dynamics. Recombinant technology allows for the production and study of HIST1H2AA in controlled environments, facilitating investigations into its structural properties, post-translational modifications, and interactions with other chromatin-associated proteins. Furthermore, studies of this histone variant can provide insights into the mechanisms by which histones influence epigenetic regulation and their role in cellular responses to environmental stimuli. Understanding the functional roles of HIST1H2AA could pave the way for novel therapeutic approaches targeting chromatin-related diseases, making it a significant focus of current research in molecular biology and medicine.
