Analytical Data
-
基因名
CD66e/CEACAM5
-
简介
CEACAM5 protein is a cell surface glycoprotein that cooperates with carcinoembryonic antigen-related molecules (such as CEACAM6) to participate in cell adhesion, intracellular signaling, and tumor progression. CEACAM5 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived CEACAM5 protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag.
- Application
-
别名
Carcinoembryonic antigen; CEA; Meconium antigen 100; CD66e
-
种属
Human
-
表达系统
HEK293
-
标签
C-Avi;C-6*His
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
P06731
-
表达区间
K35-A685
-
氨基酸序列
KLTIESTPFNVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITVSASGTSPGLSA
-
蛋白长度
Full Length of Mature Protein
-
分子量
110-150 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CD66e, also known as CEACAM5 or Carcinoembryonic Antigen (CEA), is a member of the carcinoembryonic antigen (CEA) family of glycoproteins, which are primarily expressed in epithelial tissues and play a crucial role in cell adhesion and signaling. The significance of CD66e in cancer biology, particularly in colorectal and other gastrointestinal cancers, has made it a focal point of research due to its overexpression in various malignancies. Its involvement in tumor progression, metastasis, and immune evasion highlights the potential of CD66e as a therapeutic target and a biomarker for cancer diagnosis and monitoring. The development of recombinant CD66e proteins allows for detailed studies on its biological functions and interactions, paving the way for innovative therapeutic approaches, including monoclonal antibody development and targeted drug delivery systems. Additionally, understanding the structural and functional characteristics of CD66e through recombinant expression enhances the knowledge of its role in tumor biology, potentially leading to novel diagnostic and treatment strategies for patients with CD66e-expressing tumors. The exploration of CD66e/CEACAM5 in the context of immunotherapy and its ability to modulate immune responses further underscores the relevance of this protein in contemporary cancer research. Overall, the study of CD66e/CEACAM5 recombinant proteins holds promise not only for advancing our understanding of cancer mechanisms but also for improving clinical outcomes through targeted therapeutic interventions.
