Analytical Data
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基因名
THOC1
- Application
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别名
HPR1; P84; P84N5; Nuclear matrix protein p84
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96FV9
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表达区间
Lys133~Ser560
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分子量
62kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
THOC1 (THO complex subunit 1) is a crucial component of the THO complex, which plays a significant role in the transport of mRNA from the nucleus to the cytoplasm and is involved in various aspects of gene expression regulation. Recent studies have highlighted its significance in RNA metabolism, influencing processes such as mRNA processing, stability, and export. Dysregulation of THOC1 has been implicated in several diseases, including certain cancers and neurodegenerative disorders, underscoring its potential as a therapeutic target. Researchers have been focusing on the structural and functional characterization of THOC1 as a recombinant protein to better understand its mechanisms of action and interactions with other cellular components. High-level expression and purification of THOC1 as a recombinant protein enable detailed biophysical and biochemical analyses, which can provide insights into its role within the THO complex and its impact on mRNA-related processes. Further investigation into the modulation of THOC1 activity may yield new strategies for clinical intervention in diseases linked to aberrant mRNA metabolism, making it a focal point for ongoing research in molecular biology and therapeutic development.
