Analytical Data
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Gene name
THOC1
- Application
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Alternative Names
HPR1; P84; P84N5; Nuclear matrix protein p84
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96FV9
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Expression Region
Lys133~Ser560
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Molecular Weight
62kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
THOC1 (THO complex subunit 1) is a crucial component of the THO complex, which plays a significant role in the transport of mRNA from the nucleus to the cytoplasm and is involved in various aspects of gene expression regulation. Recent studies have highlighted its significance in RNA metabolism, influencing processes such as mRNA processing, stability, and export. Dysregulation of THOC1 has been implicated in several diseases, including certain cancers and neurodegenerative disorders, underscoring its potential as a therapeutic target. Researchers have been focusing on the structural and functional characterization of THOC1 as a recombinant protein to better understand its mechanisms of action and interactions with other cellular components. High-level expression and purification of THOC1 as a recombinant protein enable detailed biophysical and biochemical analyses, which can provide insights into its role within the THO complex and its impact on mRNA-related processes. Further investigation into the modulation of THOC1 activity may yield new strategies for clinical intervention in diseases linked to aberrant mRNA metabolism, making it a focal point for ongoing research in molecular biology and therapeutic development.
