Analytical Data
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Gene name
TFDP1
- Application
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Alternative Names
DP1; DRTF1; DRTF1-polypeptide 1; E2F dimerization partner 1
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Species
Human
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Source
E. coli
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Tag
N- His & GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q14186
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Expression Region
Gly6~Thr335
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Molecular Weight
75kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TFDP1, or Transcription Factor Dp-1, is a critical protein involved in the regulation of cell cycle and gene expression, particularly in the context of E2F transcription factors. Its role in cellular processes such as proliferation, apoptosis, and differentiation has made TFDP1 a significant focus of research, especially in cancer biology. Abnormal expression or mutation of TFDP1 has been implicated in various types of cancers, suggesting its potential as a biomarker for tumor progression and a target for therapeutic intervention. The intricate interactions between TFDP1 and E2F family members highlight its importance in the transcriptional regulation of genes essential for cell cycle progression. Understanding the structure and function of TFDP1 through recombinant technology has allowed researchers to dissect its molecular mechanisms and interactions, paving the way for novel strategies to manipulate its activity in clinical settings. This research also emphasizes the need for detailed studies on the post-translational modifications and signaling pathways that involve TFDP1, further corroborating its relevance in both normal developmental processes and pathological conditions. The exploration of TFDP1 as a therapeutic target holds promise for the development of innovative cancer treatments, providing a deeper insight into the molecular underpinnings of tumorigenesis and highlighting the pivotal role of transcriptional regulation in maintaining cellular homeostasis.
