Analytical Data
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基因名
TCIRG1
- Application
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别名
Stv1; Vph1; ATP6N1C; ATP6V0A3; Atp6i; OC-116kDa; OC116; OPTB1; TIRC7; a3; V-Type Proton ATPase 116 kDa Subunit A Isoform 3; Osteoclastic proton pump 116 kDa subunit
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13488
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表达区间
Arg49~Val348
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分子量
38kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TCIRG1, or T-cell immune regulator 1, plays a critical role in the immune system by regulating the function of T cells, which are essential for adaptive immunity. Mutations in the TCIRG1 gene are linked to autosomal recessive osteopetrosis, a disorder characterized by excessive bone density due to impaired osteoclast function. This has garnered significant interest in the research community, as understanding the mechanisms governing TCIRG1 can provide insights into both bone metabolism and immune regulation. The recombinant protein form of TCIRG1 has been studied for its potential therapeutic applications, particularly in bone disorders and immune-related diseases. Research has focused on elucidating the structural and functional properties of the TCIRG1 protein, which may aid in the development of gene therapies or protein replacement strategies for affected individuals. Additionally, TCIRG1 serves as a valuable model for exploring the intricate interplay between the immune system and bone health, offering promising avenues for innovative treatments in both fields.
