Analytical Data
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Gene name
PYGO2
- Application
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Species
Human
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Source
E. coli
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Tag
N- His & GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BRQ0
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Expression Region
Leu171~Gly406
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Molecular Weight
54kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PYGO2 (PYGO domain-containing protein 2) is a crucial component of the Wnt signaling pathway, which plays a significant role in various biological processes including cell proliferation, differentiation, and stem cell maintenance. As a transcriptional co-activator, PYGO2 interacts with β-catenin, facilitating the transcription of Wnt target genes that are essential for embryonic development and tissue homeostasis. Dysregulation of Wnt signaling, often due to aberrant PYGO2 activity, has been implicated in several diseases, including cancers and developmental disorders. Despite its importance, the structural and functional characteristics of recombinant PYGO2 have not been extensively investigated. Studying the recombinant form of PYGO2 offers insights into its molecular mechanisms and interactions, which could reveal potential therapeutic targets for Wnt-related diseases. Furthermore, the ability to produce and purify recombinant PYGO2 allows for in-depth biochemical assays, structural biology studies, and the screening of small molecules that could modulate its activity. This research aims to understand the role of PYGO2 in Wnt signaling and uncover its potential as a biomarker or therapeutic target in various pathologies, ultimately contributing to the development of innovative strategies for disease intervention.
