Analytical Data
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Gene name
DVL2
- Application
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Alternative Names
Segment polarity protein dishevelled homolog DVL-2
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O14641
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Expression Region
Leu78~Thr250
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Molecular Weight
27kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
DVL2, or Dishevelled segment polarity protein 2, is a key component of the Wnt signaling pathway, which is crucial for various cellular processes including cell differentiation, polarity, and proliferation. The Wnt pathway plays a significant role in developmental biology and has been implicated in numerous diseases, including cancer. Research on DVL2 has gained considerable attention because of its involvement in the regulation of signaling cascades that can influence embryonic development and tissue homeostasis. The protein acts as a critical mediator that transduces signals from Wnt ligands to downstream effectors, making it essential for understanding how aberrations in this pathway contribute to pathological conditions. Recombinant DVL2 protein has been produced to facilitate in-depth studies of its structure and function, allowing researchers to investigate its interactions with other proteins, as well as its role in cell signaling. By utilizing advanced techniques such as X-ray crystallography and cryo-electron microscopy, scientists aim to elucidate the molecular mechanisms by which DVL2 operates within the Wnt pathway. Understanding the dynamics of DVL2 not only helps illuminate fundamental biological processes but also holds potential for therapeutic intervention in Wnt-related disorders. Thus, the study of DVL2 and its recombinant forms is a growing field, promising insights into both normal physiology and the underlying mechanisms of diseases linked to Wnt signaling dysregulation.
