Analytical Data
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Gene name
DTX1
- Application
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Alternative Names
hDx-1; E3 ubiquitin-protein ligase DTX1
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q86Y01
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Expression Region
Gly290~His535
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Molecular Weight
30kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DTX1, or Deltex homolog 1, is an E3 ubiquitin ligase that plays a critical role in various cellular processes, including signal transduction, cell differentiation, and apoptosis. It is particularly known for its involvement in the Notch signaling pathway, where it functions as a positive regulator, influencing the fate of developing cells in various tissues. Dysregulation of DTX1 has been implicated in several diseases, including cancer, where altered Notch signaling contributes to tumorigenesis and poor prognosis. Recent studies have highlighted the potential of DTX1 as a therapeutic target, making the characterization and understanding of DTX1's function essential. Given its significance, research into DTX1 recombinant protein serves multiple purposes: elucidating its molecular mechanisms, screening for small-molecule inhibitors, and finding ways to modulate its activity. Additionally, by utilizing recombinant technology, researchers can produce high-purity DTX1 protein for structural studies and functional assays, ultimately paving the way for novel therapeutic strategies against diseases associated with DTX1 misregulation. Therefore, understanding DTX1 through recombinant protein studies is a promising frontier in both basic and translational research, with the potential to uncover new avenues for the treatment of Notch-related disorders.
