Analytical Data
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Gene name
PVALB
- Application
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Species
Rat
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Source
E. coli
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Tag
N-His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
P02625
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Expression Region
Ser2~Ser110
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Molecular Weight
16kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PVALB (Parvalbumin) is a calcium-binding protein that plays a crucial role in the nervous system, particularly in the functioning of inhibitory interneurons. These interneurons are essential for maintaining the balance of excitation and inhibition in neural circuits, which is vital for proper cognitive and motor functions. Dysfunctions in PVALB-expressing neurons have been implicated in several neurological and psychiatric disorders, including schizophrenia, autism spectrum disorders, and epilepsy. Research on PVALB recombinant proteins aims to better understand their structure, function, and interactions, providing insights into how PVALB contributes to synaptic plasticity and calcium signaling. By producing and characterizing recombinant PVALB, scientists can investigate its biophysical properties, its role in neuronal excitability, and how its dysregulation may lead to pathological conditions. Additionally, recombinant PVALB can serve as a valuable tool for studying calcium dynamics in live neurons and developing novel therapeutic strategies to target specific neural pathways implicated in disorders associated with PVALB dysfunction. This research is particularly relevant for potential interventions in conditions where PVALB levels or activity are altered, emphasizing the importance of understanding this protein's biological significance in neurobiology and medicine.
