Analytical Data
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基因名
EOMES
- Application
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别名
TBR2; T-Box Brain 2
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种属
Human
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表达系统
E. coli
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标签
N- His & GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O95936
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表达区间
Leu400~Ser669
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分子量
60.1kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
EOMES (Eomesodermin) is a T-box transcription factor crucial for various developmental processes, particularly in the formation of mesoderm and early embryogenesis. Its role extends to the regulation of immune cell differentiation, particularly in T cell development and function. Research has shown that EOMES is pivotal for the differentiation of CD8+ T cells, influencing their effector functions and memory formation. Additionally, aberrant EOMES expression has been implicated in various pathological conditions, including certain types of cancer and autoimmune diseases, highlighting its importance in both normal physiology and disease. The study of EOMES recombinant proteins facilitates a deeper understanding of its structural and functional characteristics, enabling researchers to investigate its mechanism of action in cellular contexts. By generating EOMES in a recombinant form, researchers can analyze its interactions with other proteins, its binding affinity to DNA, and its influence on gene expression. This provides valuable insights into how EOMES regulates key biological processes and can lead to therapeutic strategies targeting EOMES-related pathways in diseases. Understanding the role of EOMES through recombinant protein studies may not only advance our knowledge of developmental biology but also contribute to the development of novel immunotherapies and treatments for immune-related disorders.
