Analytical Data
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Gene name
EOMES
- Application
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Alternative Names
TBR2; T-Box Brain 2
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Species
Human
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Source
E. coli
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Tag
N- His & GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O95936
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Expression Region
Leu400~Ser669
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Molecular Weight
60.1kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
EOMES (Eomesodermin) is a T-box transcription factor crucial for various developmental processes, particularly in the formation of mesoderm and early embryogenesis. Its role extends to the regulation of immune cell differentiation, particularly in T cell development and function. Research has shown that EOMES is pivotal for the differentiation of CD8+ T cells, influencing their effector functions and memory formation. Additionally, aberrant EOMES expression has been implicated in various pathological conditions, including certain types of cancer and autoimmune diseases, highlighting its importance in both normal physiology and disease. The study of EOMES recombinant proteins facilitates a deeper understanding of its structural and functional characteristics, enabling researchers to investigate its mechanism of action in cellular contexts. By generating EOMES in a recombinant form, researchers can analyze its interactions with other proteins, its binding affinity to DNA, and its influence on gene expression. This provides valuable insights into how EOMES regulates key biological processes and can lead to therapeutic strategies targeting EOMES-related pathways in diseases. Understanding the role of EOMES through recombinant protein studies may not only advance our knowledge of developmental biology but also contribute to the development of novel immunotherapies and treatments for immune-related disorders.
