Analytical Data
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基因名
PVALB
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简介
PVALB Protein, also known as parvalbumin, plays a key role in muscle tissue by facilitating relaxation after contraction. Its function involves binding two calcium ions, indicating a crucial role in regulating calcium dynamics within muscle cells. Parvalbumin's ability to sequester calcium underscores its significance in fine-tuning the balance between contraction and relaxation, contributing to overall muscle physiology control. PVALB Protein, Human (His) is the recombinant human-derived PVALB protein, expressed by E. coli , with C-6*His labeled tag.
- Application
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别名
Parvalbumin Alpha; PVALB
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种属
Human
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表达系统
E. coli
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标签
C-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P20472
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表达区间
S2-S110
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蛋白长度
Full Length of Mature Protein
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分子量
14 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PVALB (Parvalbumin) is a calcium-binding protein that plays a crucial role in the nervous system, particularly in the functioning of inhibitory interneurons. These interneurons are essential for maintaining the balance of excitation and inhibition in neural circuits, which is vital for proper cognitive and motor functions. Dysfunctions in PVALB-expressing neurons have been implicated in several neurological and psychiatric disorders, including schizophrenia, autism spectrum disorders, and epilepsy. Research on PVALB recombinant proteins aims to better understand their structure, function, and interactions, providing insights into how PVALB contributes to synaptic plasticity and calcium signaling. By producing and characterizing recombinant PVALB, scientists can investigate its biophysical properties, its role in neuronal excitability, and how its dysregulation may lead to pathological conditions. Additionally, recombinant PVALB can serve as a valuable tool for studying calcium dynamics in live neurons and developing novel therapeutic strategies to target specific neural pathways implicated in disorders associated with PVALB dysfunction. This research is particularly relevant for potential interventions in conditions where PVALB levels or activity are altered, emphasizing the importance of understanding this protein's biological significance in neurobiology and medicine.
