Analytical Data
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Gene name
TGOLN2
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简介
The TGOLN2 protein plays a critical role in regulating membrane trafficking into and out of the trans-Golgi network (TGN), suggesting its critical function in coordinating vesicle trafficking within TGN-associated cellular compartments. Studying the mechanism of TGOLN2 can provide insights into its role in intracellular trafficking and membrane tissue maintenance. TGOLN2 Protein, Human (HEK293, His) is the recombinant human-derived TGOLN2 protein, expressed by HEK293 , with C-6*His labeled tag.
- Application
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Alternative Names
Trans-Golgi network integral membrane protein 2; TGN38 homolog; TGN46; TGN48; Trans-Golgi network protein TGN51; TGOLN2; TGN46; TGN51
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Species
Human
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Source
HEK293
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Tag
C-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O43493-1
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Expression Region
A22-E381
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AA Sequence
ATESVKQEEAGVRPSAGNVSTHPSLSQRPGGSTKSHPEPQTPKDSPSKSSAEAQTPEDTPNKSGAEAKTQKDSSNKSGAEAKTQKGSTSKSGSEAQTTKDSTSKSHPELQTPKDSTGKSGAEAQTPEDSPNRSGAEAKTQKDSPSKSGSEAQTTKDVPNKSGADGQTPKDGSSKSGAEDQTPKDVPNKSGAEKQTPKDGSNKSGAEEQGPIDGPSKSGAEEQTSKDSPNKVVPEQPSRKDHSKPISNPSDNKELPKADTNQLADKGKLSPHAFKTESGEETDLISPPQEEVKSSEPTEDVEPKEAEDDDTGPEEGSPPKEEKEKMSGSASSENREGTLSDSTGSEKDDLYPNGSGNGSAE
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Protein Length
Partial
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Molecular Weight
68.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TGOLN2, also known as trans-Golgi network integral membrane protein 2, is a crucial component of the Golgi apparatus, playing a significant role in protein sorting and trafficking within the cell. Research on TGOLN2 has gained momentum due to its involvement in various cellular processes, including vesicular transport, cell signaling, and maintenance of Golgi structure. Abnormalities in TGOLN2 function have been linked to several diseases, including cancer and neurodegenerative disorders, suggesting its potential as a therapeutic target. Scientists are investigating the molecular mechanisms underlying TGOLN2's role in these diseases, aiming to uncover how disruptions in its function can lead to pathological states. Additionally, the recombinant expression and purification of TGOLN2 have become essential for structural studies and for understanding its interactions with other cellular proteins. By elucidating the structure and function of TGOLN2, researchers hope to provide insights into its biological significance and pave the way for novel therapeutic strategies in disease management.
