Analytical Data
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基因名
TGOLN2
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简介
The TGOLN2 protein plays a critical role in regulating membrane trafficking into and out of the trans-Golgi network (TGN), suggesting its critical function in coordinating vesicle trafficking within TGN-associated cellular compartments. Studying the mechanism of TGOLN2 can provide insights into its role in intracellular trafficking and membrane tissue maintenance. TGOLN2 Protein, Human (HEK293, His) is the recombinant human-derived TGOLN2 protein, expressed by HEK293 , with C-6*His labeled tag.
- Application
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别名
Trans-Golgi network integral membrane protein 2; TGN38 homolog; TGN46; TGN48; Trans-Golgi network protein TGN51; TGOLN2; TGN46; TGN51
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种属
Human
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表达系统
HEK293
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标签
C-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O43493-1
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表达区间
A22-E381
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氨基酸序列
ATESVKQEEAGVRPSAGNVSTHPSLSQRPGGSTKSHPEPQTPKDSPSKSSAEAQTPEDTPNKSGAEAKTQKDSSNKSGAEAKTQKGSTSKSGSEAQTTKDSTSKSHPELQTPKDSTGKSGAEAQTPEDSPNRSGAEAKTQKDSPSKSGSEAQTTKDVPNKSGADGQTPKDGSSKSGAEDQTPKDVPNKSGAEKQTPKDGSNKSGAEEQGPIDGPSKSGAEEQTSKDSPNKVVPEQPSRKDHSKPISNPSDNKELPKADTNQLADKGKLSPHAFKTESGEETDLISPPQEEVKSSEPTEDVEPKEAEDDDTGPEEGSPPKEEKEKMSGSASSENREGTLSDSTGSEKDDLYPNGSGNGSAE
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蛋白长度
Partial
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分子量
68.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TGOLN2, also known as trans-Golgi network integral membrane protein 2, is a crucial component of the Golgi apparatus, playing a significant role in protein sorting and trafficking within the cell. Research on TGOLN2 has gained momentum due to its involvement in various cellular processes, including vesicular transport, cell signaling, and maintenance of Golgi structure. Abnormalities in TGOLN2 function have been linked to several diseases, including cancer and neurodegenerative disorders, suggesting its potential as a therapeutic target. Scientists are investigating the molecular mechanisms underlying TGOLN2's role in these diseases, aiming to uncover how disruptions in its function can lead to pathological states. Additionally, the recombinant expression and purification of TGOLN2 have become essential for structural studies and for understanding its interactions with other cellular proteins. By elucidating the structure and function of TGOLN2, researchers hope to provide insights into its biological significance and pave the way for novel therapeutic strategies in disease management.
