Analytical Data
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基因名
ADAM28
- Application
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别名
ADAM23; MDCL; eMDCII; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein L; Epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein II
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UKQ2
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表达区间
Glu525~Lys774
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分子量
34kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ADAMTS10 (A Disintegrin and Metalloproteinase with Thrombospondin Motifs 10) is a member of the ADAMTS family, which is characterized by its unique structure and function in extracellular matrix (ECM) remodeling. It plays a crucial role in the processing of various proteins, including aggrecan, an essential component of cartilage and other connective tissues. Mutations in the ADAMTS10 gene have been linked to specific genetic disorders, such as Weill-Marchesani syndrome, which is characterized by short stature, skeletal anomalies, and eye abnormalities. The study of recombinant ADAMTS10 protein is significant for understanding its molecular mechanisms and interactions within the ECM, as well as its implications in various pathologies. Investigating the functional properties of ADAMTS10 through recombinant protein production allows researchers to analyze its enzymatic activity, identify substrate specificity, and explore potential therapeutic targets for disorders associated with its dysfunction. This research aids in unraveling the complex pathways influenced by ADAMTS10 and contributes to developing strategies for treating related conditions, thereby highlighting its importance in both developmental biology and clinical research.
