Analytical Data
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基因名
ITM2B
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简介
The ITM2B protein regulates amyloid beta A4 precursor protein (APP) processing by inhibiting amyloid beta peptide aggregation and fibril deposition. In addition to its effects on the amyloid-β pathway, ITM2B also contributes to neurite outgrowth, affecting neurobiological processes. ITM2B Protein, Human (HEK293, His) is the recombinant human-derived ITM2B protein, expressed by HEK293 , with C-6*His labeled tag.
- Application
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别名
Integral Membrane Protein 2B; Immature BRI2; imBRI2; Protein E25B; Transmembrane Protein BRI; Bri; ITM2B; BRI; BRI2
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种属
Human
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表达系统
HEK293
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标签
C-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y287
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表达区间
Y76-S266
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氨基酸序列
YKYFALQPDDVYYCGIKYIKDDVILNEPSADAPAALYQTIEENIKIFEEEEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPRNLLELLINIKAGTYLPQSYLIHEHMVITDRIENIDHLGFFIYRLCHDKETYKLQRRETIKGIQKREASNCFAIRHFENKFAVETLICS
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蛋白长度
Lumenal Domain
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分子量
29-33 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ITM2B (Integral Membrane Protein 2B) is a member of the ITM2 family, known for its role in mediating various cellular processes, including signaling and protein-protein interactions. Its implications in neurodegenerative diseases, particularly Alzheimer's disease, have garnered significant research interest. Advances in our understanding of ITM2B's functions suggest that it may influence amyloid beta processing and synaptic integrity, thus contributing to cognitive decline. Furthermore, its potential as a therapeutic target has prompted studies focusing on the structural and functional characterization of ITM2B, particularly in relation to its membrane topology and interactions with other proteins. These investigations aim to elucidate the mechanisms by which ITM2B might modulate neuronal health and disease, providing insights into its role in pathophysiological conditions and the development of novel treatment strategies. Given the growing prevalence of neurodegenerative disorders, understanding the molecular intricacies of ITM2B and its associated pathways is crucial for identifying targeted interventions that can mitigate disease progression and improve patient outcomes.
