Analytical Data
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Gene name
LRRC3B
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简介
LRRC3B Protein is a leucine-rich repeat-containing transmembrane protein. LRRC3B, a tumor suppressor, is invovled in carcinogenesis, and the expression is down-regulated in gastric, breast, colon, testis, prostate, and brain cancers. But LRRC3B is up-regulated in the virus infected group. LRRC3B is involved in plant and animal immunity, hormone-receptor interactions, cell adhesion, signal transduction, regulation of gene expression, and apoptosis[1][2][3]. LRRC3B Protein, Human (HEK293, His) is the recombinant human-derived LRRC3B protein, expressed by HEK293 , with C-6*His labeled tag.
- Application
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Alternative Names
Leucine-Rich Repeat-Containing Protein 3B; Leucine-Rich Repeat Protein LRP15; LRRC3B; LRP15
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Species
Human
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Source
HEK293
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Tag
C-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96PB8
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Expression Region
C34-Y204
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Protein Length
Partial
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Molecular Weight
20-29 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LRRC3B (Leucine-rich repeat-containing protein 3B) is a member of the leucine-rich repeat (LRR) protein family, which plays vital roles in various biological processes, including signal transduction, cell adhesion, and immune responses. Recent studies have highlighted the potential involvement of LRRC3B in cancer biology, particularly in tumor progression and metastasis. The aberrant expression of LRRC3B has been associated with several malignancies, suggesting that it may function as a tumor suppressor or an oncogene depending on the context. Given its significance, researchers are exploring the development of recombinant LRRC3B proteins to investigate their structural and functional properties, aiming to uncover the molecular mechanisms underlying its role in cellular processes. Advances in recombinant protein technology facilitate the expression and purification of LRRC3B, enabling detailed studies using biochemical assays, cellular models, and potentially therapeutic applications. Understanding the precise function and interactions of LRRC3B could provide valuable insights into its role in health and disease, paving the way for novel therapeutic strategies targeting LRRC3B in cancer treatment and other related disorders.
