Analytical Data
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基因名
TM4SF1 Protein-VLP, Cynomolgus
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简介
TM4SF1 Protein-VLP, Cynomolgus (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.
- Application
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别名
M3S1; TAAL6; H-L6; L6
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种属
Cynomolgus
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表达系统
HEK293
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标签
C-10*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
A0A2K5VKY2
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表达区间
M1-C202
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氨基酸序列
MCYGKCARCIGHSLVGLALLCIIANILLYFPNGETKYASENHLSRFVWFFSGIVGGGLLMLLPAFVFIGLEQDDCCGCCGHENCGKRCAMLSSVLAALIGIAGSGYCVIVAALGLAEGPLCLDSFGQWNYTFASTEGQYLLDTSTWSQCTEPKHIVEWNVSLFSILLALGGIEFILCLIQVINGVLGGICGFCCSRQQQYDC
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蛋白长度
Full Length
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TM4SF1 (Transmembrane 4 L Six Family Member 1) is a tetraspanin protein primarily implicated in various cellular processes, including cell proliferation, differentiation, and migration. Its expression has been linked to tumor progression and metastasis in several cancer types, making it a compelling target for therapeutic intervention. In the context of vaccine development, the generation of Virus-Like Particles (VLPs) has garnered significant attention due to their ability to mimic the structure of viruses while lacking viral genetic material, thereby providing a robust platform for antigen delivery and immune response elicitation. Research on Cynomolgus macaques as a model organism is particularly pertinent due to their genetic, anatomical, and physiological similarities to humans, which enhance the translational potential of findings. The development of recombinant TM4SF1 protein-VLPs represents an innovative approach to harness the immunogenic properties of TM4SF1, potentially improving vaccine formulations or therapeutic strategies against TM4SF1-expressing tumors. These studies aim to elucidate the protein's role in immune modulation and to assess the VLP's efficacy in inducing an immune response, paving the way for novel cancer immunotherapies or vaccines.
