Analytical Data
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Gene name
GNaS1
- Application
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Alternative Names
NESP55; NESP; GNASXL; GPSA; SCG6; Secretogranin VI; Adenylate cyclase-stimulating G alpha protein; Guanine Nucleotide Binding Protein Alpha Stimulating Activity Polypeptide 1
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P63092
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Expression Region
Gly2~Leu380
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Molecular Weight
49kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GNaS1, or the guanine nucleotide-binding protein, alpha stimulating 1, plays a crucial role in various cellular signaling pathways, particularly in the regulation of adenylate cyclase, which catalyzes the conversion of ATP to cyclic AMP. This process is vital for numerous physiological functions, including hormone signaling, neurotransmission, and metabolic regulation. Abnormalities in GNaS1 function have been implicated in several diseases, such as congenital hyperinsulinism and certain endocrine tumors. As a result, understanding the structure and function of GNaS1 is essential for elucidating its role in health and disease. Research into the recombinant expression of GNaS1 protein allows scientists to obtain large quantities of pure protein for biochemical and biophysical studies, enabling detailed analysis of its interactions with receptors and effectors in signaling pathways. Moreover, characterizing GNaS1's structure can provide insights into its mechanism of action and potential therapeutic targets. Advances in recombinant DNA technology have facilitated the production of GNaS1 in various expression systems, paving the way for more in-depth investigations into its biological functions and the development of novel interventions for related disorders. This research is not only fundamental for basic science but also holds translational potential in the context of drug development and precision medicine.
