Analytical Data
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Gene name
Integrin alpha V beta 8
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简介
Integrin alpha V beta 3 (ITGAV:ITGB3) functions as a receptor for CD40LG, enhancing Lilrb4a inhibitory effects on mast cell activation. It suppresses marginal zone B cell antibody production through Lilrb4a interaction. ITGAV:ITGB3, forming a heterodimer with ITGAV, interacts with ligands such as RAB25, CIB1, FBLN5, and more. It also forms a complex with PTPRZ1 and PTN, stimulating endothelial cell migration. Integrin alpha V beta 8 Protein, Mouse (HEK293, His) is a recombinant protein dimer complex containing mouse-derived Integrin alpha V beta 8 protein, expressed by HEK293 , with C-His labeled tag. Integrin alpha V beta 8 Protein, Mouse (HEK293, His), has molecular weight of 80-140 kDa.
- Application
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Alternative Names
αVβ8; Integrin alpha V beta 8; ITGAV&ITGB8; Integrin alpha V β 8
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Species
Mouse
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Source
HEK293
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Tag
C-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P43406 (F31-V988)&Q0VBD0
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Expression Region
P43406 (F31-V988)&Q0VBD0 (G22-S679)
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Molecular Weight
80-140 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Integrin alpha V beta 8 is a heterodimeric cell adhesion receptor that plays a significant role in various biological processes, including cell migration, proliferation, and differentiation. It is primarily involved in the interactions between cells and the extracellular matrix, which are crucial for tissue development and immune responses. The integrin is expressed in several cell types, including epithelial cells, immune cells, and certain tumor cells, suggesting its potential importance in both physiological and pathological contexts. Recent studies have highlighted its involvement in cancer progression, particularly in the tumor microenvironment, where it may facilitate the invasion and metastasis of cancer cells. Furthermore, integrin alpha V beta 8 has been implicated in regulating immune responses, particularly in the context of T cell activation and polarization. As a result, this integrin has emerged as a promising target for therapeutic interventions in cancer and autoimmune diseases. Researchers are increasingly focusing on producing recombinant forms of integrin alpha V beta 8 to better understand its structure-function relationships and to investigate its potential as a biomarker or therapeutic target. Recombinant proteins can be utilized in a variety of experimental settings, including binding assays, functional studies, and development of inhibitors, paving the way for novel treatment strategies aimed at modulating integrin-mediated processes in disease. Thus, the study of integrin alpha V beta 8 not only sheds light on fundamental biological mechanisms but also opens up avenues for innovative clinical applications in treating various diseases.
