Analytical Data
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基因名
DYNC1H1
- Application
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别名
DHC1; DHC1a; DNCH1; DNCL; DNECL; DYHC; Dnchc1; HL-3; p22; Dynein heavy chain, cytosolic; Cytoplasmic dynein heavy chain 1; Cytoplasmic dynein 1 heavy chain 1
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q14204
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表达区间
Ala20~Leu285
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分子量
34kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DYNC1H1, a gene encoding the cytoplasmic dynein heavy chain, plays a critical role in intracellular transport and organelle positioning. This motor protein is essential for retrograde transport along microtubules, facilitating the movement of cellular components, including vesicles and organelles, towards the cell center. Dysregulation or mutations in DYNC1H1 have been linked to various neurological disorders, such as spinal muscular atrophy and intellectual disabilities, highlighting its significance in neuronal health and function. Research on DYNC1H1 recombinant proteins aims to elucidate its structural and functional mechanisms, providing insights into its role in cellular pathways and disease processes. By producing and studying these recombinant proteins, scientists can explore the protein's interactions with other cellular components, its motor activity, and the effects of specific mutations. This research not only contributes to fundamental biological understanding but also holds potential for developing therapeutic strategies targeting DYNC1H1-related disorders, thereby addressing important aspects of neurobiology and molecular medicine.
