Analytical Data
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Gene name
MTFMT
- Application
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Alternative Names
FMT1
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Species
Mouse
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9D799
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Expression Region
Val78~Ser386
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Molecular Weight
38kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MTFMT (mitochondrial methionyl-tRNA formyltransferase) is a crucial enzyme involved in the initiation of protein synthesis within mitochondria. It catalyzes the formylation of methionine, resulting in formylmethionine (fMet), which serves as the first amino acid in mitochondrial protein translation. The study of MTFMT has gained prominence due to its significant role in mitochondrial biology and the implications of mitochondrial dysfunction in a variety of diseases, including neurodegenerative disorders and certain forms of cancer. Mitochondria are essential for cellular energy production and play a pivotal role in metabolism, thus understanding MTFMT can provide insights into the broader mechanisms underlying mitochondrial function. Recent research has also suggested that mutations or dysfunctions in the MTFMT gene can lead to severe mitochondrial diseases, highlighting the enzyme’s potential as a therapeutic target. By investigating MTFMT's structure, function, and interactions within the mitochondrial translation machinery, scientists aim to elucidate its precise role and develop strategies to mitigate the effects of mitochondrial-related pathologies. This research not only deepens our understanding of mitochondrial genetics but also opens new avenues for therapeutic interventions in diseases where mitochondrial function is compromised.
