Analytical Data
-
Gene name
Synaptotagmin VI
-
简介
The Ptk7 protein is a receptor involved in multiple cellular processes, including cell proliferation and migration. It plays a crucial role in regulating embryonic development and tissue homeostasis. Synaptotagmin VI Protein, Human (N-His) is the recombinant human-derived Synaptotagmin VI protein, expressed by E. coli , with N-His labeled tag.
- Application
-
Alternative Names
Synaptotagmin-6; Synaptotagmin VI; SytVI; SYT6
-
Species
Human
-
Source
E. coli
-
Tag
N-His
-
Purity
Greater than 95% as determined by SDS-PAGE.
-
Uniprot
NP_995320
-
Expression Region
V275-L425
-
Protein Length
Partial
-
Molecular Weight
19 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Synaptotagmin VI (Syt VI) is a member of the synaptotagmin family of proteins, which are crucial for calcium-mediated neurotransmitter release in the nervous system. It contains multiple C2 domains that bind calcium ions, playing a significant role in synaptic vesicle trafficking and exocytosis. Research has shown that Syt VI is involved in regulating the release of various neurotransmitters, including GABA and glutamate, and particularly influences synaptic transmission in both central and peripheral nervous systems. The study of Syt VI is particularly important for understanding synaptic plasticity and neuronal communication, as alterations in its expression or function have been implicated in various neurodevelopmental disorders and neurodegenerative diseases. Recombinant Syt VI proteins are often utilized in biochemical and biophysical studies to elucidate their functional mechanisms, including their interactions with phospholipids and involvement in synaptic vesicle fusion. By expressing Syt VI in vitro, researchers can dissect the precise roles of its different domains under varying calcium concentrations and membrane environments, leading to insights into the molecular underpinnings of neurotransmission and potential therapeutic targets for synaptic dysfunctions.
