Analytical Data
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Gene name
TGFBI
- Application
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Alternative Names
Transforming growth factor-beta-induced protein ig-h3; Beta ig-h3; RGD-CAP; BIGH3
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Species
Human
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Source
HEK293
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Tag
C-10*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q15582
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Expression Region
G24-H683
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AA Sequence
GPAKSPYQLVLQHSRLRGRQHGPNVCAVQKVIGTNRKYFTNCKQWYQRKICGKSTVISYECCPGYEKVPGEKGCPAALPLSNLYETLGVVGSTTTQLYTDRTEKLRPEMEGPGSFTIFAPSNEAWASLPAEVLDSLVSNVNIELLNALRYHMVGRRVLTDELKHGMTLTSMYQNSNIQIHHYPNGIVTVNCARLLKADHHATNGVVHLIDKVISTITNNIQQIIEIEDTFETLRAAVAASGLNTMLEGNGQYTLLAPTNEAFEKIPSETLNRILGDPEALRDLLNNHILKSAMCAEAIVAGLSVETLEGTTLEVGCSGDMLTINGKAIISNKDILATNGVIHYIDELLIPDSAKTLFELAAESDVSTAIDLFRQAGLGNHLSGSERLTLLAPLNSVFKDGTPPIDAHTRNLLRNHIIKDQLASKYLYHGQTLETLGGKKLRVFVYRNSLCIENSCIAAHDKRGRYGTLFTMDRVLTPPMGTVMDVLKGDNRFSMLVAAIQSAGLTETLNREGVYTVFAPTNEAFRALPPRERSRLLGDAKELANILKYHIGDEILVSGGIGALVRLKSLQGDKLEVSLKNNVVSVNKEPVAEPDIMATNGVVHVITNVLQPPANRPQERGDELADSALEIFKQASAFSRASQRSVRLAPVYQKLLERMKH
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Protein Length
Full Length of Mature Protein
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Molecular Weight
75 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TGFBI, or Transforming Growth Factor Beta Induced, is a gene encoding a protein that plays a crucial role in various biological processes, including cell adhesion, migration, and proliferation. Research into TGFBI has gained significant attention due to its involvement in several pathological conditions, such as fibrosis, cancer, and corneal diseases. The TGFBI protein, also known as βIG-H3, is a member of the matricellular protein family and is primarily expressed in the extracellular matrix, where it interacts with integrins and growth factors, influencing cellular responses. Studies have shown that alterations in TGFBI expression and mutations can lead to various clinical manifestations, such as corneal dystrophies, indicating its importance in maintaining tissue integrity. Researchers have been focusing on generating recombinant TGFBI protein to better understand its structural and functional properties, elucidate its role in disease mechanisms, and explore its potential therapeutic applications. The recombinant forms are increasingly used in experimental settings to investigate the protein's interactions, signaling pathways, and impact on cellular behavior. This approach promises to enhance the understanding of TGFBI's multifaceted role in health and disease, paving the way for novel strategies in treating conditions associated with TGFBI dysregulation. Overall, TGFBI recombinant protein research is pivotal for unraveling its biological functions and developing targeted therapeutic interventions.
