Analytical Data
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Gene name
RTN4
- Application
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Alternative Names
NSP; ASY; NOGO; NSP-CL; RTN-X; Reticulon-5; Foocen; Neurite outgrowth inhibitor; Neuroendocrine-specific protein; Neuroendocrine-specific protein C homolog
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NQC3
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Expression Region
Val566~Phe748
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Molecular Weight
36kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
RTN4, also known as reticulon-4, is a member of the reticulon protein family, which plays a critical role in various cellular processes, including endoplasmic reticulum (ER) morphology and neuroprotection. Research into RTN4 has garnered attention due to its significant involvement in neuronal function and its implications in neurodegenerative diseases. In particular, RTN4 has been identified as a key regulator of apoptosis, with studies showing that it can inhibit neuronal cell death in conditions such as cerebral ischemia and neuroinflammation. Furthermore, the interplay between RTN4 and its receptors, such as Nogo receptor 1 (NgR1), is crucial for understanding its role in axonal regeneration and repair mechanisms following central nervous system injuries. The development of RTN4 recombinant proteins has allowed for detailed studies of its functional properties and interactions, providing insights into potential therapeutic targets for enhancing neural repair. Given the increase in interest around regenerative medicine and neuroprotection strategies, investigating RTN4 offers a promising avenue for advancing treatment methodologies for injuries and diseases affecting the nervous system.
