Analytical Data
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基因名
ZBP1
- Application
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别名
DNA-dependent activator of IFN-regulatory factors; DAI; Tumor stroma and activated macrophage protein DLM-1; ZBP1
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种属
Mouse
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表达系统
HEK293
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标签
C-6*His;C-Flag
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9QY24
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表达区间
M1-Q411
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氨基酸序列
MAEAPVDLSTGDNLEQKILQVLSDDGGPVKIGQLVKKCQVPKKTLNQVLYRLKKEDRVSSPEPATWSIGGAASGDGAPAIPENSSAQPSLDERILRFLEANGPHRALHIAKALGMTTAKEVNPLLYSMRNKHLLSYDGQTWKIYHSRQEGQDIAHSGVTQESPAIICQHNPVNMICQQGANSHISIANSNAIQIGHGNVIVREKACGEPGPRTSHPLPLAWDASAQDMPPVAHGAQYIYMDKSLLQQVQLGHHNEMSLVGDAGKHPSYSFSDSPPEVSTTTADPGASFNMQTFEPGPHPEGDTVQTVHIKSCFLEDATIGNGNKMTIHLRSKGEVMESGDSEEPKKEDTGTSSEATPPRSCQHTPSDSMLPTSELRAMALGDSSPQTTEPVLREHEVQDIESSQDTGLSKQ
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蛋白长度
Full Length
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分子量
65 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ZBP1 (Z-DNA binding protein 1) is a crucial protein involved in various cellular processes, particularly in the response to viral infections and stress conditions. Initially identified for its ability to bind Z-DNA, ZBP1 has been shown to play a significant role in the innate immune response by recognizing and responding to cytosolic viral DNA, thereby activating signaling pathways that lead to the production of type I interferons and other cytokines. The recognition of Z-DNA and other nucleic acid structures by ZBP1 underscores its function as a sensor for viral constituents, which is integral to the body's defense mechanisms. Recent studies have highlighted its involvement in apoptosis and autophagy, further emphasizing its significance beyond immune responses. Research into recombinant ZBP1 has gained momentum due to its potential therapeutic applications, particularly in enhancing antiviral responses and understanding auto-inflammatory disorders. By producing recombinant ZBP1, researchers aim to delve deeper into its biochemical properties, functional interactions, and potential as a target for drug development. Such studies are essential for elucidating the molecular mechanisms underlying ZBP1-mediated pathways, paving the way for innovative therapeutic strategies that harness the body's innate defenses against infections and other diseases. As our understanding of ZBP1 evolves, it may offer new insights into disease mechanisms and therapeutic interventions in infectious and inflammatory conditions.
