Cat: IPD-X39046

Recombinant Human Grb10 Protein,His

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Analytical Data

  • 基因名

    Grb10

  • Application

    SPRMSTBLIITCELISA细胞实验药物筛选

  • 别名

    GRB-IR; IRBP; MEG1; RSS; GRB10 adapter protein; Insulin receptor-binding protein Grb-IR

  • 种属

    Human

  • 表达系统

    E. coli

  • 标签

    N-His

  • 纯度

    Greater than 90% as determined by SDS-PAGE.

  • 蛋白编号

    Q13322

  • 表达区间

    Thr392~Leu594

  • 分子量

    27kDa

  • 内毒素

    < 1.0 EU per μg protein as determined by the LAL method.

  • 性状

    Freeze-dried powder

  • 缓冲液

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • 复溶方法

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • 个性化定制

    点位突变 标签定制 buffer定制 全长蛋白定制

  • 稳定性测试

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • 保存条件 & 期限

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • 运输条件

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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Protein Description

Grb10 (Growth factor receptor-bound protein 10) is a crucial adaptor protein that plays significant roles in cellular signaling processes, particularly in the regulation of growth factor signaling, insulin signaling, and neuronal development. It is known to interact with various receptor tyrosine kinases and can modulate their activity, influencing critical cellular functions like proliferation, differentiation, and metabolism. Abnormalities in Grb10 function have been implicated in several diseases, including obesity, diabetes, and certain cancers. Due to its pivotal role in these pathways, researchers are increasingly focused on elucidating the structure and function of Grb10 as a means to understand its biological significance and potential therapeutic applications. The generation of recombinant Grb10 protein has become a key area of interest, enabling the investigation of its molecular interactions and biological roles in a controlled environment. By studying the recombinant form of Grb10, scientists aim to explore its interactions with other signaling molecules, characterize its functions in various cellular contexts, and assess its potential as a biomarker or therapeutic target in metabolic and oncological diseases. This research is instrumental not only in advancing our understanding of Grb10 as a critical player in cellular signaling but also in paving the way for the development of novel strategies for treating related disorders.

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IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
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