Analytical Data
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Gene name
Grb10
- Application
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Alternative Names
GRB-IR; IRBP; MEG1; RSS; GRB10 adapter protein; Insulin receptor-binding protein Grb-IR
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q13322
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Expression Region
Thr392~Leu594
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Molecular Weight
27kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Grb10 (Growth factor receptor-bound protein 10) is a crucial adaptor protein that plays significant roles in cellular signaling processes, particularly in the regulation of growth factor signaling, insulin signaling, and neuronal development. It is known to interact with various receptor tyrosine kinases and can modulate their activity, influencing critical cellular functions like proliferation, differentiation, and metabolism. Abnormalities in Grb10 function have been implicated in several diseases, including obesity, diabetes, and certain cancers. Due to its pivotal role in these pathways, researchers are increasingly focused on elucidating the structure and function of Grb10 as a means to understand its biological significance and potential therapeutic applications. The generation of recombinant Grb10 protein has become a key area of interest, enabling the investigation of its molecular interactions and biological roles in a controlled environment. By studying the recombinant form of Grb10, scientists aim to explore its interactions with other signaling molecules, characterize its functions in various cellular contexts, and assess its potential as a biomarker or therapeutic target in metabolic and oncological diseases. This research is instrumental not only in advancing our understanding of Grb10 as a critical player in cellular signaling but also in paving the way for the development of novel strategies for treating related disorders.
