Analytical Data
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Gene name
PNR
- Application
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Alternative Names
NR2E3; PNR; ESCS; RNR; Rd7; Nuclear Receptor Subfamily 2,Group E,Member 3; Protein tailless homolog; Nuclear receptor TLX
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Species
Human
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Source
E. coli
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Tag
N- His & GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y5X4
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Expression Region
Met1~Asn410
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Molecular Weight
75kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PNR (Peroxisome Proliferator-Activated Receptor Nucleotide) is a crucial member of the nuclear receptor superfamily, playing a significant role in regulating gene expression involved in various physiological processes, including metabolism, inflammation, and cell differentiation. Research has shown that PNR is activated by specific ligands, leading to the modulation of target genes related to lipid metabolism and energy homeostasis. Given the increasing prevalence of metabolic disorders such as obesity and diabetes, PNR has garnered attention as a potential therapeutic target. Studies have demonstrated that PNR is implicated in the regulation of adipogenesis and insulin sensitivity, suggesting its critical role in maintaining metabolic health. Additionally, PNR's involvement in inflammatory responses has prompted investigations into its potential in managing chronic inflammatory diseases. Understanding the mechanisms of PNR activation and its downstream effects at the molecular level can provide insights into innovative treatment strategies. Efforts to engineer recombinant PNR proteins have advanced our knowledge of its structure-function relationships, allowing for the exploration of selective PNR modulators that could enhance therapeutic efficacy while minimizing side effects. This ongoing research holds promise for developing new pharmacological agents targeting PNR, ultimately contributing to better management of metabolic and inflammatory diseases.
