Analytical Data
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基因名
PDGF R beta
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简介
PDGF R beta Protein is a tyrosine protein kinase that plays an important role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. PDGF R beta Protein, Canine (HEK293, His) is the recombinant canine-derived PDGF R beta protein, expressed by HEK293 , with C-His labeled tag.
- Application
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别名
JTK12; PDGF R beta; PDGFR; PDGFR1; PDGFRB; CD140B; PDGFR-2; PDGFR-β; PDGF R β
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种属
Canine
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表达系统
HEK293
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标签
C-8*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q6QNF3
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表达区间
G32-V532
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蛋白长度
Partial
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分子量
70-100 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Platelet-derived growth factor receptor beta (PDGFR-β) is a critical receptor involved in various cellular processes, including cell proliferation, survival, and migration, playing a significant role in development, wound healing, and tissue repair. Aberrant activation of PDGFR-β is implicated in a variety of pathological conditions such as cancer, fibrosis, and cardiovascular diseases. Consequently, understanding PDGFR-β signaling pathways and its interactions with ligands has become a focal point in biomedicine. Recombinant PDGFR-β proteins are utilized in research to elucidate the receptor's structure-function relationships and to develop therapeutic strategies targeting PDGFR-β in diseases. The production of these recombinant proteins, typically through techniques such as recombinant DNA technology and expression systems in bacteria or mammalian cells, allows for detailed studies of the receptor's biochemical properties and biological activities. Insights gained from such research can aid in the design of small-molecule inhibitors or monoclonal antibodies that specifically target PDGFR-β, offering potential treatments for conditions where its dysregulation is a contributing factor. Thus, the study of PDGFR-β recombinant proteins is vital in advancing our understanding of its role in health and disease, and holds promise for the development of innovative therapeutic approaches.
