Analytical Data
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Gene name
TR4
- Application
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Alternative Names
NR2C2; TAK1; TR2R1; hTAK1; Nuclear Receptor Subfamily 2,Group C,Member 2; Orphan nuclear receptor TAK1
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P49116
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Expression Region
Leu371~Leu596
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Molecular Weight
29kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TR4 (Testicular Receptor 4) is a member of the nuclear receptor superfamily that plays crucial roles in various physiological processes, including reproductive development, metabolism, and cellular differentiation. Research on TR4 has gained momentum in recent years due to its potential implications in health and disease. The receptor regulates gene expression by binding to specific DNA sequences, influencing the transcription of target genes involved in metabolic pathways and hormonal responses. Dysregulation of TR4 has been linked to various conditions, including obesity, diabetes, and certain cancers, making it a target for therapeutic intervention. Further, TR4 is involved in processes such as spermatogenesis and immune responses, highlighting its multifaceted roles in both male and female biology. Understanding the structure-function relationship of TR4 and its interactions with co-regulators through recombinant protein studies is essential for elucidating its mechanisms of action. The development of recombinant TR4 proteins provides a valuable tool for investigating its signaling pathways and may facilitate the discovery of novel drugs targeting TR4-related pathways, ultimately offering new strategies in managing diseases associated with TR4 dysregulation. As research continues, the elucidation of TR4’s roles in various biological processes may contribute to innovative therapeutic approaches in both endocrinology and oncology.
