Analytical Data
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Gene name
CYP5A1
- Application
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Alternative Names
TBXAS1; TS; CYP5; THAS; TXAS; TXS; Thromboxane A Synthase 1(Platelet); Cytochrome P450 Family 5 Subfamily A Polypeptide 1
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P24557
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Expression Region
Leu357~Arg533
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Molecular Weight
24kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CYP5A1, a member of the cytochrome P450 enzyme family, plays a critical role in the metabolism of various endogenous compounds and xenobiotics. This enzyme is particularly involved in the biosynthesis of bioactive lipids and sterols, which are essential for numerous physiological functions. Research has indicated that CYP5A1 may be implicated in various diseases, including cardiovascular conditions and certain types of cancer, due to its involvement in regulating inflammatory responses and oxidative stress. Given its significance, the production of recombinant CYP5A1 protein has become a focal point for scientists aiming to elucidate its structure-function relationships and to explore its potential as a therapeutic target. By utilizing advanced expression systems, researchers can generate large quantities of functional CYP5A1 for biochemical assays and crystallographic studies, paving the way for the development of small molecule inhibitors or modulators that could impact disease pathways linked to this enzyme. Understanding the enzymatic mechanisms of CYP5A1 and its interactions with various substrates is crucial for leveraging its biological roles in health and disease. Moreover, the characterization of CYP5A1 can facilitate the discovery of biomarkers for disease diagnosis and treatment monitoring, thereby highlighting its relevance in pharmacology and personalized medicine. Overall, the study of recombinant CYP5A1 not only enhances the understanding of cytochrome P450 enzymes but also opens new avenues for therapeutic interventions in related diseases.
