Analytical Data
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基因名
KLRG2
- Application
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别名
C-type lectin domain family 15 member B
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种属
Human
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表达系统
Yeast
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
A4D1S0
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表达区间
1-409aa
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分子量
44.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KLRG2, or Killer Cell Lectin Like Receptor G2, is a crucial member of the C-type lectin-like receptor family predominantly expressed on natural killer (NK) cells and certain T lymphocyte subsets. Its role in immune regulation has garnered significant attention in recent years, as KLRG2 is involved in the inhibition of effector functions and the modulation of cell survival, linking it to immune tolerance and exhaustion in chronic infections and cancer. Research indicates that KLRG2 negatively regulates the activation of NK cells and T cells, which suggests its potential as a therapeutic target for enhancing anti-tumor immunity or reinvigorating exhausted immune cells. Additionally, understanding the structural and functional characteristics of KLRG2, particularly through the development of recombinant proteins, provides valuable insights into its ligand interactions and downstream signaling pathways. These studies aim to delineate the receptor's mechanisms in immune responses and explore its application in immunotherapy strategies. As a result, the recombinant KLRG2 protein serves as a valuable tool for investigating its role in immunological contexts and for exploring new avenues in treatment modalities for various diseases, including malignancies and chronic viral infections. The exploration of KLRG2's functions and interactions represents a promising frontier in immunology, potentially leading to novel therapeutic approaches leveraging this receptor for better immune system modulation.
