Analytical Data
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Gene name
CRHR2
- Application
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Alternative Names
CRFR2; CRF2; Corticotropin-releasing factor receptor 2
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Species
Rat
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
D4A5C4
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Expression Region
Met1~Lys108
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Molecular Weight
15kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Corticotropin-releasing hormone receptor 2 (CRHR2) is a key component of the hypothalamic-pituitary-adrenal (HPA) axis, playing an essential role in the body's response to stress. It primarily mediates the effects of corticotropin-releasing hormone (CRH), influencing various physiological and behavioral responses. Research has shown that CRHR2 is implicated in modulating anxiety, depression, and other stress-related disorders, making it a potential target for therapeutic interventions. The study of CRHR2 recombinant proteins has gained prominence, as these proteins can be used to elucidate receptor function, signaling pathways, and pharmacodynamics. By generating CRHR2 in recombinant systems, researchers can produce large quantities of the functional receptor, facilitating structural and functional analyses, drug discovery, and the development of CRHR2-specific ligands. The understanding of CRHR2's interactions with its ligands and downstream signaling mechanisms is crucial for interpreting its role in neurobiology, particularly in the context of stress-related pathologies. Furthermore, the exploration of CRHR2 as a therapeutic target holds promise for novel treatment strategies in mental health disorders, underscoring the importance of ongoing research in this domain.
