Analytical Data
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基因名
KCNK2
- Application
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别名
Outward rectifying potassium channel protein TREK-1 TREK-1 K(+) channel subunit Two pore domain potassium channel TREK-1 Two pore potassium channel TPKC1
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种属
Human
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表达系统
Yeast
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O95069
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表达区间
1-143aa
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分子量
17.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KCNK2, also known as TASK-2 (TWIK-related acid-sensitive K+ channel 2), belongs to the two-pore domain potassium channel family, which plays a crucial role in maintaining the resting membrane potential and regulating neuronal excitability. Research on KCNK2 has gained significant attention due to its involvement in various physiological processes, including the modulation of neuronal signaling, cardiac function, and the regulation of smooth muscle contraction. Dysregulation of KCNK2 has been linked to several pathologies, such as epilepsy, hypertension, and psychiatric disorders, making it an important target for therapeutic intervention. The study of KCNK2 recombinant protein has provided insights into its structural and functional properties, facilitating the understanding of its role in cellular mechanisms. Recombinant KCNK2 is often expressed in heterologous systems, enabling researchers to investigate its ion channel activity, pharmacological properties, and interactions with other proteins. Overall, the research surrounding KCNK2 recombinant protein aims to uncover its potential as a drug target and enhance our understanding of its physiological significance in health and disease.
