Analytical Data
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Gene name
APBB3
- Application
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Alternative Names
APB-B3; SRA; FE65L2; FE65-L2; Fe65L2 isoform 484; Alzheimer's beta-amyloid interaction protein; Amyloid beta (A4) protein-binding, family B, member 3, isoform CRA_g
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Species
Rat
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O35827
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Expression Region
Asn14~Ala302
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Molecular Weight
36kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
APBB3 (Amyloid Precursor Protein-Binding Family B Member 3) is a protein that has garnered significant interest in recent years due to its potential implications in neurodegenerative diseases, particularly Alzheimer's disease. This protein is involved in various cellular processes, including signal transduction and gene expression, and has shown affinity for binding to amyloid precursor proteins, which play a crucial role in the pathogenesis of Alzheimer's. The aggregation of amyloid-beta peptides, derived from these precursor proteins, is a hallmark of Alzheimer's pathology. Researchers have been investigating the functional role of APBB3 in modulating neuronal survival and synaptic function, as its interaction with other molecular partners may influence these critical processes. Moreover, mutations or dysregulation of APBB3 may contribute to the susceptibility or progression of neurodegenerative conditions. The study of APBB3, therefore, aims to elucidate its biological functions, investigate its potential as a therapeutic target, and enhance our understanding of Alzheimer’s disease mechanisms. The development of recombinant APBB3 protein allows for detailed structural and functional studies, paving the way for novel therapeutic strategies and biomarker identification in neurodegeneration. As research progresses, insights into APBB3 could unlock new avenues for treatment, ultimately contributing to improved outcomes for individuals affected by dementia-related disorders.
