Analytical Data
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Gene name
APBB2
- Application
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Alternative Names
APB-B2; FE65L; FE65L1; Fe65-like; Amyloid beta A4 precursor protein-binding family B member 2
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Species
Human
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Source
E. coli
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Tag
N- His & GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q92870
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Expression Region
Asp413~Pro758
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Molecular Weight
66kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The APBB2 protein, or amyloid precursor protein-binding protein 2, is a member of the family of proteins that interact with the amyloid precursor protein (APP), which is critically involved in the pathogenesis of Alzheimer's disease. Given the role of APP in producing amyloid-beta peptides that aggregate in the brains of Alzheimer's patients, research into the APBB2 protein has gained significant interest. APBB2 is believed to influence APP processing, thereby affecting amyloid-beta production. Further studies have shown that APBB2 may play a role in synaptic function and regulation of proteins involved in neural signaling. Understanding the functional dynamics of APBB2 may provide insights into the molecular mechanisms underlying cognitive decline and the development of Alzheimer's disease. Additionally, the exploration of APBB2 as a potential therapeutic target could offer new avenues for intervention in neurodegenerative diseases. By investigating its structure, function, and interaction with APP and other cellular components, researchers aim to clarify the multifaceted roles of APBB2 in neuronal health and disease, contributing to the broader understanding of Alzheimer’s pathology and potential treatment strategies.
