Analytical Data
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Gene name
APPBP2
- Application
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Alternative Names
PAT1; Protein Interacting With APP Tail 1,Cytoplasmic Tail; Amyloid protein-binding protein 2; Protein interacting with APP tail 1
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Species
Rat
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
A5HK05
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Expression Region
Lys396~Cys585
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Molecular Weight
26kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
APPBP2, also known as Amyloid Precursor Protein Binding Protein 2, is a crucial molecule involved in several cellular processes, particularly in the context of Alzheimer's disease. It interacts with the Amyloid Precursor Protein (APP), influencing its processing and the subsequent production of amyloid-beta peptides, which aggregate to form plaques in the brains of Alzheimer's patients. Research into APPBP2 has expanded to explore its role in protein homeostasis, apoptosis, and cellular signaling pathways. The understanding of APPBP2's functions has implications not only for neurodegenerative diseases but also for cancer and neurodevelopmental disorders. Given its pivotal role in APP metabolism, APPBP2 has become a target for therapeutic interventions aimed at modulating amyloid-beta production. Investigating the structure and function of APPBP2 can provide insights into its potential as a biomarker for disease progression and as a target for drug development, thus holding promise for novel strategies in the prevention and treatment of Alzheimer's and related disorders. The study of APPBP2’s recombinant protein serves as a foundation for further elucidating its biological roles and interactions, ultimately contributing to our understanding of complex neurobiological mechanisms.
