Analytical Data
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Gene name
SNAP25
- Application
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Alternative Names
RIC4; SEC9; SNAP; SUP; Super protein; Resistance To Inhibitors Of Cholinesterase 4 Homolog
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Species
Human, Mouse, Rat
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
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Expression Region
Met1~Gly206
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Molecular Weight
27kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SNAP25 (Synaptosomal-Associated Protein of 25 kDa) is a crucial protein involved in synaptic transmission and plays a significant role in the exocytosis process at the neuromuscular junction and central nervous system synapses. It is a member of the SNARE (Soluble N-ethylmaleimide-sensitive factor Attachment Protein Receptor) protein family, which facilitates the fusion of synaptic vesicles with presynaptic membranes, enabling the release of neurotransmitters. Dysregulation or mutations in SNAP25 have been linked to several neuropsychiatric and neurological disorders, including schizophrenia, epilepsy, and attention deficit hyperactivity disorder (ADHD). As research continues to explore the molecular mechanisms underlying synaptic communication, recombinant SNAP25 proteins have become essential tools for studying protein interactions and function in vitro. Scientists utilize recombinant SNAP25 to investigate its role in neurotransmitter release, study binding interactions with other SNARE proteins, and examine its involvement in disease models. These studies enhance our understanding of synaptic dynamics and could further lead to the development of therapeutic strategies that target SNAP25-related pathways to treat neurological disorders. Overall, the study of recombinant SNAP25 proteins is integral to elucidating the complex processes of neurobiology and could pave the way for novel interventions in the treatment of synaptic dysfunctions.
