Analytical Data
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基因名
Cortactin
- Application
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别名
EMS1; Cortical Actin binding Protein; Src substrate cortactin; Amplaxin; Oncogene EMS1
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种属
Rat
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q66HL2
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表达区间
Met1~Gln509
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分子量
76kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Cortactin is a multifunctional protein that plays a critical role in actin dynamics and cell motility. Its significance has been highlighted in various cellular processes, including cell adhesion, migration, and invadopodia formation. Cortactin is known to interact with the actin cytoskeleton and regulate the assembly of actin filaments, making it essential for implementing cellular architecture and signaling pathways. Abnormalities in cortactin expression or function have been implicated in various diseases, particularly cancer, where it contributes to enhanced invasive potential and metastasis of tumor cells. Research on the recombinant expression of cortactin proteins is essential for elucidating its structural and functional properties, as well as its mechanisms of action in cellular contexts. By producing recombinant cortactin, researchers can study its interactions with other molecules, including actin-binding proteins and signaling factors, providing valuable insights into its role in health and disease. Understanding the precise mechanisms by which cortactin influences actin dynamics and cellular behavior could lead to the identification of potential therapeutic targets for preventing or mitigating cancer progression and other cortactin-related pathologies.
