Analytical Data
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Gene name
ITPR3
- Application
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Alternative Names
IP3-R; ITPR3; IP3R3; IP3 receptor isoform 3; Type 3 inositol 1,4,5-trisphosphate receptor
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Species
Human
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Source
E. coli
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Tag
N- His & GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q14573
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Expression Region
Phe2389~Asp2496
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Molecular Weight
42kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ITPR3 (Inositol 1,4,5-trisphosphate receptor type 3) is a critical protein involved in cellular signaling pathways, particularly those modulating calcium release from the endoplasmic reticulum. Understanding ITPR3's functions and interactions is essential due to its implications in various physiological processes and its association with several diseases, including neurodegenerative disorders and cancers. Recent studies have highlighted its role in neuronal signaling, cardiac function, and immune responses, indicating its importance in maintaining cellular homeostasis. The reconstitution of ITPR3 can facilitate in-depth functional assays and structural studies, providing insights into how this receptor modulates intracellular calcium levels and impacts cellular responses. By employing recombinant DNA technology and protein expression systems, researchers aim to produce a high-quality, functional ITPR3 protein for biochemical analyses. This research is significant in unraveling the specific mechanisms of ITPR3 in health and disease, potentially leading to the development of targeted therapeutic strategies that could mitigate the effects of dysregulated calcium signaling. Understanding ITPR3's role further could also pave the way for innovations in drug design, making it a focal point in both molecular biology and clinical research.
