Analytical Data
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基因名
FOLH1
- Application
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别名
Cell growth-inhibiting gene 27 proteinFolate hydrolase 1Folylpoly-gamma-glutamate carboxypeptidase ;FGCPGlutamate carboxypeptidase II ;GCPIIMembrane glutamate carboxypeptidase ;mGCPN-acetylated-alpha-linked acidic dipeptidase I ;NAALADase IProstate-specific membrane antigen ;PSM ;PSMAPteroylpoly-gamma-glutamate carboxypeptidase
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种属
Human
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q04609
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表达区间
48-750aa
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分子量
83.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FOLH1, or Folate Hydrolase 1, is a critical enzyme involved in folate metabolism, playing a significant role in the hydrolysis of polyglutamated folates into their monoglutamate forms, which are more bioavailable for cellular uptake. Elevated levels of FOLH1 have been associated with various pathological conditions, including cancer, where it contributes to tumor growth by modulating folate availability and influencing cellular proliferation. The enzyme is also of interest in neurological disorders, as it affects folate levels essential for neurotransmitter synthesis and neural function. Research into recombinant FOLH1 has gained momentum, focusing on its potential as a target for therapeutic interventions and as a biomarker for disease progression. The development of recombinant protein allows for detailed structural and functional studies, paving the way for drug design that could inhibit FOLH1's activity or modify its substrate interactions. Novel applications in imaging and targeted therapy, especially in oncology, are being explored, as FOLH1 appears to be overexpressed in certain cancers, providing a selective target for drug delivery systems. Overall, the study of FOLH1 recombinant protein is crucial not only for understanding fundamental biochemical processes but also for the development of innovative strategies in disease treatment and prevention.
