Analytical Data
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基因名
ROM1
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简介
ROM1 protein is involved in rod outer segment (ROS) morphogenesis, and may work with PRPH2 to maintain the structure of the curved intervertebral disc and organize ROS, thus affecting the intervertebral disc diameter. In addition, ROM1 is involved in protecting the retinal outer nuclear layer. ROM1 Protein, Human (His) is the recombinant human-derived ROM1 protein, expressed by E. coli , with N-His labeled tag.
- Application
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别名
Rod outer segment membrane protein 1; ROSP1; Tspan-23; ROM1; TSPAN23
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种属
Human
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表达系统
E. coli
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标签
N-6*His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
Q03395
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表达区间
P126-D263
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蛋白长度
Partial
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分子量
18 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ROM1 (Retinal Outer Segment Membrane Protein 1) is a critical protein predominantly expressed in the photoreceptor cells of the retina, playing an essential role in the integrity and function of photoreceptor outer segments. Research on ROM1 has gained prominence due to its involvement in photoreceptor cell structure and its implications in retinal diseases, including retinitis pigmentosa and other forms of inherited retinal dystrophies. Understanding the biochemical properties and function of ROM1 is vital, as mutations in the ROM1 gene can disrupt photoreceptor organization, leading to vision loss. Moreover, ROM1 exists as a homomeric and heteromeric complex with other membrane proteins, particularly peripherin-2, contributing to the formation of the disc membranes that are critical for capturing light stimuli. Investigations into the structure, function, and interactions of ROM1 at the molecular level are essential for uncovering the mechanisms underlying phototransduction and retinal health. Additionally, exploring the potential of ROM1 as a therapeutic target or biomarker for retinal diseases has become a focal point for researchers, aiming to develop innovative strategies for diagnosis and treatment of retinal degenerative conditions. As advancements in molecular biology techniques improve, the potential for creating model systems to better understand ROM1's role in health and disease continues to grow, offering promising avenues for future research and therapeutic interventions.
